Extremely dense breast tissue is a risk factor for breast cancer and limits the detection of breast cancer with mammography. Although study results show that MR imaging (MRI) added to screening mammography helps find more cancers, the effect of supplemental imaging has not been examined in randomized controlled trials. The Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial is the first randomized trial to investigate the additional value of MRI for women with extremely dense breasts within the Dutch population-based biennial mammography screening program.

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